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For some patients with unfavorable genetic profiles for monotherapy, dual activation provides the breakthrough needed to achieve sustained weight loss
In the STEP 1 trial, the 2.4 mg dose led to an average weight loss of 14.9% over 68 weeks
Parvathaneni A, McQuitty EN, Slawin B, et al
The peptide backbone of these compounds tends to undergo degradation in the infant gastrointestinal tract, further limiting systemic absorption if any traces enter breast milk
But counterintuitively, its getting worse over time
