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A: The primary difference is their FDA-approved usage and maximum dosage, even though both medications contain the exact same active ingredient (semaglutide)

GCGR co-agonism is the key structural differentiator from tirzepatide

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Rossing P, Filippatos G, Agarwal R et al (2022) Finerenone in predominantly advanced CKD and type 2 diabetes with or without sodium-glucose cotransporter-2 inhibitor therapy

Daily ICV injections of OXM over 7 days led to food intake reduction and increased weight loss compared with saline treated controls ( Concurrent to the pre-clinical studies, the first human study of oxyntomodulin was carried out in a small double-blind placebo-controlled crossover study ( ad-libitum food intake was significantly reduced in participants receiving OXM compared to saline control and a cumulative caloric intake reduction was observed up to 12 hours later