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In addition, the choroid plexus and adipose tissue both produce tryptase, which can induce mast cell activation, ultimately leading to increased intracranial pressure

LudvikBGiorginoFJDAREFriasJPFernndez LandLBrownKet al

That also could potentially undo any metabolic improvements that can go hand-in-hand with weight loss, such as in diabetes and blood pressure
