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Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohns disease

Hyperinsulinemia and insulin resistance promote tumor growth through various mechanisms: directly by activating the insulin receptor signaling pathway and indirectly by stimulating the insulin-like growth factor (IGF) receptor system, which in turn fosters cellular proliferation, migration, and invasion while inhibiting programmed cell death [11]

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