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doi: 10.1507/endocrj.EJ24-0286
Bone and muscle loss: The combination of reduced appetite and weight loss can lead to reduced muscle mass and bone density over time, especially when paired with inadequate protein intake and absence of strength training
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Starting new medications that affect glucose metabolism, appetite, or gastrointestinal function may counteract tirzepatide effects
Knowing what to expect at each phase prevents two common mistakes: getting discouraged early when the scale moves slowly, and getting impatient mid-treatment when the rate of loss naturally slows
