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Semaglutide added to basal insulin in type 2 diabetes (SUSTAIN 5): a randomized, controlled trial

Its primary physiological functions include promoting glucose-dependent insulin secretion, enhancing hepatic glycogen synthesis, and increasing the buffering capacity of adipose tissue for lipids

Regarding lipotoxicity, a study in kidneys of mice fed a high-fat diet (55) revealed that the GLP-1 receptor agonist dulaglutide changed the lipid content of the organ, including reductions in diacylglycerols, phosphatidic acids, phosphatidylglycerols, and triglycerides

No affiliation with Novo Nordisk Inc., the only US source of FDA-approved semaglutide

Experts presenting at the French Nutrition Days 2025 conference highlighted the risk of sarcopenia and lean mass loss associated with GLP-1-driven weight loss, particularly when weight loss is rapid