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Resmetirom, which was also approved in August 2025 by the European Medicines Agency (EMA), is indicated for the treatment of adults with noncirrhotic MASH with moderate to advanced fibrosis and has been administered to over 23 000 patients in the USA ( On August 15th, 2025, the FDA granted an accelerated and conditional approval of the subcutaneous glucagonlike peptide (GLP1) receptor agonist (GLP1RA) semaglutide 2.4 mg/week for the treatment of MASH with moderate to advanced fibrosis (Stage F2F3) [7]

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For example, a patient might start with phentermine for 12 weeks to kickstart weight loss and then transition to a long-term GLP-1 program for maintenance and further reduction

-10-year overall survival: 96.9% vs 76.4% -91% lower relative risk of death -67% lower risk of recurrence Cohort 3: Patients with type 2 diabetes GLP-1 users were compared with patients taking SGLT2 inhibitors like Farxiga or Jardiance (4,052/group)