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It down regulates (slows down) hormones (sex + thyroid), which makes progress even harder.

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Postprandial active GLP-1 was increased at 5% WL (P<0.01) and CCK reduced at 5 and 10% WL (P<0.01, for both) and wk 9 (P<0.001)

Out-of-Pocket Costs Drive Abandonment Especially in Obesity While payer restrictions and coverage gaps contribute to GLP-1 therapy abandonment, out-of-pocket (OOP) costs remain the most consistent and powerful predictor of non-adherence
