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when PARP-1 was overexpressed, the effects of AICAR on INS-1 cells were partially attenuated (Figures 4A,B)

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This inhibition leads to reduced steatosis and improvement of insulin sensitivity [42]

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In general, without knowing what Medicaid and Medicare generally are currently paying for these drugs on net, it is uncertain whether the lower prices that will be made available to state Medicaid programs and Part D plans under the BALANCE Model for currently covered uses of GLP-1s will generate enough savings to offset the additional costs from expanded use of these medications for obesity