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Variations in the GLP1R gene (such as rs6923761), the GIPR gene (rs1800437), and metabolic regulators like FTO (rs9939609) and MC4R (rs17782313) influence individual sensitivity to semaglutide and the likelihood of hitting a plateau

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Pharmacogenetics of selective serotonin reuptake inhibitors (SSRI): a serotonin reuptake transporter (SERT)-based approach

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The STEP program (Semaglutide Treatment Effect in People with obesity) showed participants receiving semaglutide lost between 10% and 22% of their body weight depending on dose, compared to 2.4% in the placebo group