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doi: 10.1172/jci.insight.153732 270 EmanuelEJDellgrenJLMcCoyMSPersadG

The mechanism for action for regulating glucose metabolism of OXM remains elusive but might involve a similar pathway to GLP-1 since it activates the same receptor, although OXM is still able to improve glucose metabolism in mice lacking GLP-1R 211

Long-term modeling published in Nephrology Dialysis Transplantation estimated that dapagliflozin may delay kidney failure by approximately 6.6 years (NDT, 2024)

This chronological summary highlights major historical milestones from the incretin concept through to the current generation of GLP-1-based therapies and their impacts

As an epimer of D-fructose, it follows in absorption, distribution and excretion by routes and mechanisms fructose except for lack of metabolism in mammalian cells