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Recurrent nocturnal hypoxic episodes promote oxidative stress and inflammatory activation, characterized by elevated TNF- , IL-6, and C-reactive protein levels ( 4.4 Potential effects of tirzepatide on upper airway function In addition to metabolic and inflammatory modulation, emerging evidence suggests that incretin-based therapies may influence upper airway neuromuscular control

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GLP1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebocontrolled trial

By targeting two hormones instead of one, tirzepatide, which is the only dual GLP-1/GIP agonist with FDA approval, has shown an even greater ability than other drugs to help patients lose weight