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Retatrutide would first need to complete Phase 3 trials, receive MHRA or EMA marketing authorisation, and then undergo a NICE technology appraisal before NHS prescribing could begin
Similarly, Rezaie holds GLP-1s prior to elective endoscopic procedures, including colorectal cancer screening, since their use may affect gastric motility and colonoscopy prep

Lancet 2001: 358:8934 13

For patients using GLP-1 medications or seeking sustainable alternatives and weaning tools, emerging microbiome science offers promising tools to optimize results
