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Igweokpala, S., Sule, N

But scientists now know GLP-1 receptors exist in many tissues, including immune cells

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For example, microinjection of GLP1 into the central nucleus of the amygdala has been shown to elicit conditioned taste aversion but not hypophagia, whereas targeting of the lower brainstem with fourth ventricular GLP1 injection resulted in hypophagia, but not conditioned taste aversion (Kinzig et al., 2002), and similarly, anxiety responses were preferentially elicited by GLP1 injected into the central nucleus of the amygdala, whereas ACTH and corticosterone levels were increased by administration in the paraventricular nucleus of the hypothalamus (Kinzig et al., 2003)

Both compounds cause gastrointestinal side effects like nausea and diarrhea, but mazdutide side effects are generally milder and more manageable