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Finally, publication bias cannot be excluded, especially given the increasing clinical interest in GLP-1RAs and the greater likelihood of publishing studies with favorable outcomes

These findings demonstrate the drugs potential to improve overall metabolic health and address obesity-related diseases such as liver dysfunction and metabolic dysfunction-associated steatohepatitis (MASH)

So on the headline number, the new oral GLP-1 pills sit close to the injectable semaglutide, and below high-dose tirzepatide

There are a few possible theories

Diabetes Care 46 , 384390 (2023)