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Ondansetron, metoclopramide, prochlorperazine, and promethazine are effective for manageing nausea caused by GLP-1 medications

Blood sugar levels, measured by HbA1c, fell by an average of 2.0% from a baseline of 7.9%

Sci Transl Med 5:209ra151 Finan B, Yang B, Ottaway N et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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For PRIME designation, an applicant must provide data that demonstrate a meaningful improvement of clinical outcomes (EMA, n.d.o)