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Overall psychiatric safety Large analyses have not shown an overall increase in psychiatric adverse events with GLP-1 receptor agonists and some data suggest improvements in emotional eating and restrained eating behaviors

PMID 29677303

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Wegovy may contribute to an increased risk for thyroid c-cell tumors, acute pancreatitis, gallbladder disease, hypoglyceia, acute kidney injury, severe GI side effects, and an increased risk for worsening of diabetic retinopathy in people with type 2 diabetes

Fibroblasts were transfected with the siRNAs using Lipofectamine 3000 (Invitrogen, Carlsbad, CA, USA) according to the manufacturers instructions