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Contact your healthcare provider for fever above 100.4F, severe or persistent vomiting lasting more than 24-48 hours, signs of dehydration (decreased urine output, severe dizziness), severe abdominal pain, or respiratory symptoms, as these may indicate infection or complications requiring evaluation

Nat Med (2022) 28:5918

For people with complex medical needs such as type 2 diabetes, kidney disease, gastrointestinal conditions or a history of bariatric surgery working with an APD is even more important

The importance of tirzepatides action on the GIPR in adipocytes to the medications ability to promote loss of excess adiposity has not been fully elucidated, and further research is needed
A meta-analysis across randomized controlled trials found significant reductions in body weight averaging 12.4%, BMI by 4.0 kg/m2, and waist circumference by 8.0 cm
