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Moreover, in both young and aged diabetic mice subjected to MCAO, exendin-4 treatment was shown to significantly polarize microglia/macrophages towards an anti-inflammatory M2 phenotype in the injured hemisphere compared to the non-injured hemisphere [76]

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Pharmacokinetic data showed that liraglutide has a longer half-life, about 9-13 hours [20], compared to the other short-acting GLP-1 Ras, such as exenatide (2.1 hours) [19]

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