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While these earlier drugs demonstrated the potential of GLP-1 therapy, the newer medications semaglutide, tirzepatide, and retatrutide have completely changed the game

The study reviewed records of over one million patients prescribed a GLP-1 between January 2018 and December 2023

These came in multi-dose vials, custom strengths, and sometimes combinations with B-vitamins, at a significantly lower price than brand-name options

While individual variation exists, complete absence of any effect at 4mg or higher suggests a calculation issue or a peptide potency problem

Clinical Trial Registration ClinicalTrials.gov identifier number NCT03940742