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The researchers analyzed pooled clinical trial data beyond the 24-week treatment period for patients in phase 2, OPTIC, and OPTIC-X studies who received a full course of teprotumumab, up to week 72 (51 weeks post-final teprotumumab infusion)

Dose changes can temporarily amplify fatigue as the body adjusts

The other two are approved for managing type 2 diabetes, but are commonly prescribed off label for weight loss
The total time to reach therapeutic doses is longer, but the journey is smoother
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