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GLP-1 acts through its receptors located on immune cells, reducing the production of inflammatory cytokines and infiltration of immune cells in the tissues

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received honoraria for speaking at meetings from Novartis, Sanofi, Lilly, Astrazeneca, and NovoNordisk

Combining GLP-1s with metformin does not appear to worsen GI side effects, despite metformin's association with similar symptoms [48]

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