glp 1 reddit weight loss 2 Years(well 25 months?) on GLP-1 Medication- thought I would share— : r/Zepbound Social media data helps AI

Posttranslational processing of preproglucagon The vast majority of glucagon is produced in the pancreatic -cells, but, under some conditions, small amounts of glucagon also have been detected in the intestinal L-cells [87], although the validity of immunoassays to distinguish different proglucagon products has been questioned, and some reports were unable to find genuine glucagon in the intestine by mass spectrometric analysis [[144], [145], [146]]

Role of ECL1 Relative to ECL2 and ECL3, ECL1 in class B GPCRs is the most divergent extracellular loop with flexible lengths, ranging from 8 (CRF2R) to 27 (PTH1R) residues

Although anesthesia-related adverse events were not observed in our cohort, the study was not powered to detect differences in uncommon but clinically important safety outcomes

Obes Surg [Internet]

Summary: Allergic reactions to GLP-1 agonists are uncommon, affecting fewer than 1 in 100 people, and range from mild injection site reactions to rare anaphylaxis requiring emergency treatment