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Drops in leptin levels, signaling lower fat stores, were observed with retatrutide, yet another indication of genuine, sustainable fat loss

Brand names like Wegovy or Zepbound can cost over $1,000 per month for the injectable drug administration

To date, these GLP-1 drugs have been approved to treat three adult populations: individuals with type 2 diabetes, individuals with a body mass index (BMI) of 30 or greater (obesity), and individuals with a BMI between 27 and 30 (overweight) with at least one weight-related health condition, such as cardiovascular disease, high blood pressure, high cholesterol, prior stroke, prior heart attack, and chest pain (angina)

This helps in managing weight and improving overall metabolic health

therefore, neurotrophic and neuroprotective activities of GLP-1RAs have been drawing increasing attention (Harkavyi and Whitton, 2010)