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Ann N Y Acad Sci 921:469472 Nauck MA, Holst JJ, Willms B, Schmiegel W (1997) Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes

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Of note, despite the high CVD risk in the patient populations in both LEADER and Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes (SUSTAIN-6), all cardiovascular risk factors, including blood pressure and LDL cholesterol, were well controlled at baseline, consistent with the high number of patients receiving statins, ACE inhibitors, angiotensin receptor blockers, and aspirin therapy

Similarly, in the SUSTAIN 7 trial, Ozempic was found to promote weight loss

Severe gastroparesis (delayed gastric emptying) is a caution or contraindication for some GLP-1 medications, as these drugs further slow gastric emptying and may exacerbate symptoms