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After 30 weeks, exenatide once weekly reduced A1C significantly more compared with the twice daily formulation (1.9% versus 1.5%

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Ozempic (Semaglutide) does not cause diverticulitis on its own, yet its most common side effects, like constipation, nausea, and slowed digestion, can mimic or worsen a flare in people who already have diverticular disease

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Moreover, prolonged agonist engagement can accelerate GLP-1R trafficking to lysosomes, reducing the availability of receptors on the cell surface for subsequent therapeutic doses [534,535,536]