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This is supported by recent evidence demonstrating that metabolic disorders such as type 2 diabetes (15, 52) and diet-induced obesity (30) are associated with downregulation in cilia genes known to be involved in proliferation, cell cycle control, and cilia motility (1) representing a potentially underexplored mechanism contributing to common obesity

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Lean chow-fed male C57BL/6 J mice were single-housed in cages equipped with a running wheel and allowed 3 days of habituation before being treated with once-daily s.c

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doi: 10.2337/db10-0674

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As more research emerges, GLP-1 medications may become a powerful adjunct therapy in rheumatologysupporting traditional treatments and improving long-term outcomes

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The development of diabetes in HS patients is particularly associated with advanced Hurley stage III, older age, and higher BMI, with patients at Hurley stage III having a markedly increased risk of developing type II diabetes compared to those at Hurley stages I and II [40]

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