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Obesity development in both rodents and humans is associated with accumulation of adipose tissue macrophages (ATMs), which propagate chronic local and systemic inflammatory responses and thereby contribute to insulin resistance (51)

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Therapy often includes: Family-based treatment Trauma-informed care Nutritional counseling focuses on restoring regular eating patterns, rebuilding trust in hunger and fullness cues, and reducing rigid food rules

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Alur-GuptaSChemerinskiALiuCLipsonJAllisonKSammelMet al
