found glp 1 GLP-1 medicines entered clinical use in 2005 as treatments for Type 2 diabetes. Over time, doctors observed their effects on appetite and body weight, leading to separate approvals for obesity About one in nine Americans
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In the subgroup analysis, although no significant differences were observed among the subgroups based on different baseline weight, control groups, and indications, significant weight regain was observed in each subgroup compared with the control group, that is, the weight regain after treatment discontinuation was consistent in obese patients with different characteristics

A large study of 2000 patients without diabetes showed that using Ozempic/Wegovy in addition to diet and exercise for 68 weeks led to a 15% weight loss (1/3 of the participants lost up to 20% of their starting weight.) Those in the control group that were only coached on the lifestyle changes lost 2.4% of their weight

doi: 10.1016/j.mce.2010.04.022

Christensen M, Sparre-Ulrich AH, Hartmann B, Grevstad U, Rosenkilde MM, Holst JJ, et al
