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54.FDA Guidance for Industry Diabetes Mellitus Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes

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That dissociation is the strongest practical argument for treating cerebrospinal fluid and plasma markers in these trials as exploratory readouts of target engagement rather than as stand-ins for benefit

However, despite their proven efficacy, challenges remain in long-term safety, adherence, and accessibility for adolescents
