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Compared with full basal-bolus insulin regimens, the combination of GLP-1 agonist plus insulin resulted in a marginal 0.1% reduction in HbA1c, a 33% lower risk of hypoglycaemia and a mean 5.66-kg reduction in weight

Methods and Guidelines for Measurement of Glucagon in Plasma

If young, healthy individuals continue to use this drug without appropriate nutritional and exercise interventions, a shift to 'sarcopenic obesity'where muscle is lost even if visible weight decreasescould occur

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In this case, it is noteworthy that the GLP-1 agonist group had no worse visual outcomes compared to the acetazolamide monotherapy group across all primary outcome measures despite the increased risk due to their higher baseline BMI, the researchers wrote in their paper