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The key is consistency over intensity

[46] investigated the effectiveness of liraglutide (3.0 mg/day) and semaglutide (1.0 mg/week) after MBS in patients who regained 15.1% of their total body weight

The results showed that at 24 weeks of treatment, Retatrutide (1mg, 4mg, 8mg or 12mg) reached the primary end point of efficacy evaluation in obese or overweight adult patients (except diabetes), with an average weight loss of 17.5%

Body weight and composition may theoretically influence drug distribution, as semaglutide binds extensively to albumin and distributes into tissues

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