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Evidence indicates that these interfaces coordinate Ca 2+ signaling microdomains, non-vesicular lipid transfer, and mitochondrial bioenergetics to maintain proteostasis, among other functions (Carreras-Sureda et al., 2022

Most patients see linear loss for 6-9 months, then 2-4 month plateau periods
Patients should promptly report any symptoms such as a lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath

--- One of the more striking takeaways from a 2024 U.S

Low self-esteem correlates with mental health issues such as depression and anxiety
