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This is one of the largest cohort studies on PLMS in the general population

Eli Lillys R&D spend on its incretin program (which includes tirzepatide, retatrutide, and orforglipron) has been roughly to billion over the last decade

the choice depends on patient preference, medical complexity, and available resources

Accordingly, and in line with currently ongoing trials in HFpEF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not

Key question: Will FDA extend enforcement discretionor leave these substances in regulatory limbo