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First-line Agents: Metformin remains foundational for those without major comorbidities

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Due to its extended half-life and structural modifications, GLP-1 is commonly selected for studies requiring prolonged receptor engagement and sustained signaling observation

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Ligand engineering and surface functionalization Target selectivity in GLP-1R-targeted nanoplatforms is achieved primarily by engineering the presentation of the peptide agonist or alternative affinity ligands on the carrier surface