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Retatrutide at 28.3% in 80 weeks is producing pharmacologically what surgery produces anatomically, and doing so with a side-effect profile that serious adverse events comparable to placebo (4% in both arms)

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doi: 10.1016/j.molmed.2016.03.005

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If you can afford both, the literature does not show meaningful additive benefit at typical doses

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2020 May;39:101113

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