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In experimental models, the ipamorelin peptide is frequently examined for its involvement in growth hormone signalling pathways and receptor-mediated cellular communication

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Its proposed mechanism of action includes stimulation of glucose-dependent insulin secretion, suppression of glucagon (via GLP-1), enhanced lipid metabolism (via GIP), and increased energy expenditure (via glucagon receptor activation)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Buse JB, Nauck M, Forst T, Sheu WH-H, Shenouda SK, Heilmann CR, Hoogwerf BJ, Gao A, Boardman MK, Fineman M, Porter L, Schernthaner G