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Tirzepatide (Mounjaro, Zepbound) is a related but distinct medication that acts as a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

26 Furthermore, a single-center, parallel-group, randomized, placebo-controlled study, which included 101 patients with biopsy-proven NASH and prediabetes or DM2 (NCT00994682), showed significant improvement of nonalcoholic fatty liver disease activity score in 58% of the patients in the pioglitazone group (vs

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Experiments conducted on PTC cell lines (GLAG-66 and TPC-1) demonstrated that silencing the DPP-IV gene using siRNA or employing the DPP-IV inhibitor, sitagliptin, resulted in a substantial reduction in the expression of key factors related to PTC pathogenesis

Abstract The uncoupling of Mitochondria-ER Contact Sites (MERCS) represents a hallmark of metabolic dysfunction in obesity and type 2 diabetes