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Cholesterol is a plasma membrane enriched lipid with pivotal roles in the control of membrane fluidity and maintenance of membrane microarchitecture, directly impacting on GPCR stability, dynamics and function

Agents in this group include antioxidants (vitamin E), tumor necrosis factor pathway regulators (emricasan, pentoxifylline, ZSP1601), and immune modulators (cenicriviroc, belapectin)

Pediatric obesity is an escalating public health concern with long-lasting metabolic, inflammatory, and psychosocial consequences (Graphical abstract)

Understanding these synergies, and how estrogen receptor-associated cotranscription factors can modulate them, represents a promising therapeutic direction to restore metabolic and reproductive health during hormonal transitions such as menopause and pregnancy.