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The potential effects of GLP-1RA on immunomodulation involving Hsp70 mechanisms in inflammatory skin diseases suggests an area for future research beyond cytokine interactions
Gorgojo-Martnez JJ, et al
While the potential mental health benefits are promising and warrant further research, its crucial to approach these medications with awareness and caution

THE BOTTOM LINE GLP-1 receptor agonists are recommended as either first-line or second-line therapy regardless of baseline hemoglobin A1c in patients who have established atherosclerotic cardiovascular disease, high risk of atherosclerotic cardiovascular disease, chronic kidney disease, or heart failure

They enhance glucose-dependent insulin secretion, suppress glucagon release, and slow gastric emptying, while supporting the preservation of pancreatic beta-cell function
