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Briefly, raw photometry signal was filtered using a Butterworth bandpass filter with 2Hz and 0.001Hz cutoffs, before it was regressed onto reference signal to eliminate potential artifacts

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When we looked at the prior literature, many of the differences in study resultssome studies finding a difference and others not finding a difference in cancer riskseemed to come from the fact that some studies do what we did, that they looked since the start of treatment and onward