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In this study, human umbilical vein endothelial cells (HUVECs), exposed to palmitic acid (PA) to induce endothelial dysfunction, were incubated with metformin, liraglutide or their combination

There's also data suggesting that in some cases, people who take GLP-1s for several years can start to experience a waning effect - perhaps a drug resistance - where they start to regain some weight, even while taking the medication

Notably, their work contributed to the development of GLP-1 drugs, which have revolutionized treatment for type 2 diabetes and obesity

Monica Padman co-hosts the weekly podcast "Armchair Expert"