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Other common goals include wanting to feel better physically and mentally as well as improving stamina, mobility, or longevity, says Allison Rhodes, MD, who is board-certified in internal and obesity medicine and practices at the Ohio State University Wexner Medical Center in Columbus

Abnormal protein clearance, mitochondrial dysfunction, and neuroinflammation also play important roles in the onset and progression of PD [80]

Originally approved for people with type 2 diabetes, several GLP-1 receptor agonists now have FDA indications for weight management, including once-weekly injectable semaglutide 2.4 mg (Wegovy, Novo Nordisk) and tirzepatide (Zepbound, Eli Lilly), an injectable GIP/GLP-1 dual incretin-based agonist

Make any changes to a patient's insulin regimen under close medical supervision with increased frequency of blood glucose monitoring

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