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In the US, 2022 Q4 sales increased by a whopping 51 percent to $363.1 million, which the company said was primarily driven by increased demand and to a lesser extent, an increased Q4 2022 royalty from Boehringer Ingelheim for exceeding certain annual thresholds. The increased demand has likely been driven by the expanded approval in heart failure, which was a significant one as Jardiance was the first drug to win approvals for the two major types of heart failure (reduced and preserved ejection fraction) in 2021 and 2022

Fatty liver disease RCTs with GLP-1 RAs, notably liraglutide and semaglutide, have demonstrated benefits in metabolic dysfunction-associated steatotic liver disease (MASLD formerly called NAFLD)

The study has two phases: a lead-in phase in which all participants take TZP and a treatment phase in which participants, after randomization, will either continue TZP or switch to placebo

Practical Guidance on GLP-1 Use While Breastfeeding Experts agree on a straightforward rule: do not start or keep taking GLP-1 medications while breastfeeding