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At least, some derivatives of berberine may

Semaglutide treatment significantly improved alanine aminotransferase (ALT) (serum glutamic-pyruvic transaminase [SGPT]) levels, along with reductions in the aspartate aminotransferase to platelet ratio index (APRI) score, liver fat content and liver stiffness

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Cognitive function was tested using the National Institute of Health Toolbox Cognitive Battery at baseline and 12 weeks