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Gastrointestinal Tolerance and Bedtime Dosing Nausea and gastrointestinal side effects occur in 20-40 percent of semaglutide users, typically peaking within the first two weeks of therapy or after dose escalation

Lifestyle Adjustments Regular Meal Timing: Skipping meals creates a "stasis" in the gallbladder

This is also true of carbonated beverages, and they can trigger bloating and stomach upset

10.1056/NEJMoa1410489 [EL 1

Many patients experience improvement after the initial weeks of treatment or following dose escalation
