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Tirzepatide works by activating both GLP-1 and GIP receptors, creating a dual effect on appetite and blood sugar regulation that lasts roughly one week after injection

Subsequent differentiation to M2 macrophages, under the influence of liraglutide treatment, also proved the anti-atherosclerotic effect of GLP-1 receptor agonist since M2 macrophages have been numerously identified in murine atherosclerosis regression models