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A retrospective cohort study found that semaglutide use was associated with a 44% reduced risk of incident cannabis use disorder (CUD) in patients with no prior history (hazard ratio [HR]: 0.56, 95% confidence interval [CI]: 0.420.75) and a 38% reduction in recurrent CUD diagnosis (HR: 0.62, 95% CI: 0.460.84) among patients with a prior history, compared to non-GLP-1RA medications [61]

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While Ozempic is more commonly prescribed, Zepbounds distinct approach to weight loss may provide an alternative for certain individuals seeking a different metabolic effect

In addition, 24 studies met the criteria for quantitative synthesis (meta-analysis)