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Tirzepatide (LY3298176) is a 39-amino acid synthetic peptide and the first approved dual agonist of the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors

(Contains Semaglutide)

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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide