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Description
Tail tip blood glucose levels were measured every 10 min using glucometers

Lancet 2018;392:2180-93.ArticlePubMed 127

As obesity rates continue to rise globally, more individuals are seeking effective pharmacological interventions

However, GcgR antagonism by MK-0893 also coincided with a 15% increase in circulating LDL-C and elevated alanine liver transaminase, which together represent adverse effects commonly seen across multiple small-molecule GcgR antagonists [31]
It enhances glucose-dependent insulin secretion, suppresses glucagon, and slows gastric emptying key mechanisms for glucose control
